Patricia I Dickson Selected Research

Iduronidase (alpha-L-Iduronidase)

1/2021	Mucopolysaccharidoses type I gene therapy.
1/2020	Intrathecal enzyme replacement for cognitive decline in mucopolysaccharidosis type I, a randomized, open-label, controlled pilot study.
3/2018	A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I.
1/2016	Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I.
9/2015	Safety of laronidase delivered into the spinal canal for treatment of cervical stenosis in mucopolysaccharidosis I.
1/2015	A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I.
1/2013	Mannose 6-phosphate conjugation is not sufficient to allow induction of immune tolerance to phenylalanine ammonia-lyase in dogs.
11/2011	Biochemical characterization of fluorescent-labeled recombinant human alpha-L-iduronidase in vitro.
5/2011	Arterial pathology in canine mucopolysaccharidosis-I and response to therapy.
12/2010	Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.

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Patricia I Dickson Research Topics

Disease

22	Mucopolysaccharidosis I (Hurler Syndrome) 03/2024 - 10/2008
13	Mucopolysaccharidoses 01/2022 - 02/2013
8	Mucopolysaccharidosis III (Sanfilippo Syndrome) 12/2022 - 03/2014
7	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2021 - 12/2010
4	Inflammation (Inflammations) 03/2024 - 01/2016
4	Spinal Cord Compression 01/2020 - 10/2008
3	Central Nervous System Diseases (CNS Diseases) 09/2018 - 06/2011
3	Brain Diseases (Brain Disorder) 12/2017 - 05/2012
2	Seizures (Absence Seizure) 03/2024 - 01/2018
2	Rhabdomyolysis 07/2023 - 11/2020
2	Cognitive Dysfunction 01/2020 - 01/2018
2	Rare Diseases (Rare Disease) 02/2016 - 06/2011
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 05/2024
1	Weight Gain 05/2024
1	Diarrhea 05/2024
1	Vascular Diseases (Vascular Disease) 03/2024
1	Coronary Artery Disease (Coronary Atherosclerosis) 03/2024
1	Liver Failure 07/2023
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 07/2023
1	VLCAD deficiency 07/2023
1	Hepatomegaly 07/2023
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2022
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 10/2022
1	Hyperthermia 01/2022
1	Hyperphagia (Overeating) 01/2022
1	Cachexia 01/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Metabolic Diseases (Metabolic Disease) 01/2021
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 11/2020
1	Cardiomyopathies (Cardiomyopathy) 11/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 11/2020
1	Hypoglycemia (Reactive Hypoglycemia) 11/2020
1	Hydrocephalus (Hydrocephaly) 01/2020
1	Kabuki syndrome 01/2020
1	Muscle Hypotonia (Hypotonia) 01/2018
1	Gliosis 01/2018
1	Ataxia (Dyssynergia) 01/2018
1	Dementia (Dementias) 10/2016
1	Nervous System Diseases (Neurological Disorders) 10/2016
1	Alzheimer Disease (Alzheimer's Disease) 10/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2016
1	Lymphoma (Lymphomas) 01/2015
1	Joint Diseases (Joint Disease) 08/2014
1	Atherosclerosis 05/2011
1	Sclerosis 05/2011
1	Hemostatic Disorders 08/2009

Drug/Important Bio-Agent (IBA)

18	EnzymesIBA 12/2022 - 12/2010
15	GlycosaminoglycansIBA 01/2021 - 10/2008
12	Iduronidase (alpha-L-Iduronidase)IBA 01/2021 - 10/2008
9	Heparitin Sulfate (Heparan Sulfate)IBA 12/2022 - 12/2010
6	Acetylglucosaminidase (NAGase)IBA 12/2022 - 03/2014
5	alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA 12/2022 - 10/2014
5	Biomarkers (Surrogate Marker)IBA 11/2019 - 02/2013
4	Mannose (D-Mannose)IBA 05/2024 - 01/2013
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2011
3	Dermatan SulfateIBA 09/2020 - 12/2010
2	CytokinesIBA 03/2024 - 01/2018
2	Fatty Acids (Saturated Fatty Acids)IBA 07/2023 - 11/2020
2	Polysaccharides (Glycans)IBA 02/2014 - 02/2013
1	FucoseIBA 05/2024
1	Guanosine Diphosphate Fucose (GDP Fucose)IBA 05/2024
1	fucokinaseIBA 05/2024
1	deschloroclozapineIBA 03/2024
1	Tripeptidyl-Peptidase 1IBA 03/2024
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 03/2024
1	Angiotensin IIIBA 03/2024
1	Losartan (Cozaar)FDA LinkGeneric 03/2024
1	Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)IBA 07/2023
1	palmitoyl-protein thioesteraseIBA 10/2022
1	N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA 01/2022
1	TrioleinIBA 01/2022
1	N-acetylglucosamine-6-sulfataseIBA 12/2021
1	Hexosaminidases (Hexosaminidase)IBA 01/2021
1	Lysergic Acid Diethylamide (LSD)IBA 01/2021
1	LipidsIBA 11/2020
1	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA 11/2020
1	Lysine (L-Lysine)FDA Link 01/2020
1	MethyltransferasesIBA 01/2020
1	Nonsense Codon (Nonsense Mutation)IBA 01/2018
1	Prednisolone (Predate)FDA LinkGeneric 01/2018
1	Cholinergic Agents (Cholinergics)IBA 10/2016
1	AntibodiesIBA 02/2016
1	ClusterinIBA 01/2016
1	Prednisone (Sone)FDA LinkGeneric 08/2014
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 03/2014
1	Peptides (Polypeptides)IBA 03/2014
1	ChondroitinIBA 02/2014
1	Hyaluronic Acid (Hyaluronan)IBA 02/2014
1	Keratan SulfateIBA 02/2014
1	AntigensIBA 01/2013
1	Claudin-5IBA 05/2011
1	DNA (Deoxyribonucleic Acid)IBA 08/2009
1	Factor VII (Proconvertin)IBA 08/2009

Therapy/Procedure

16	Enzyme Replacement Therapy 03/2024 - 10/2008
6	Therapeutics 05/2024 - 05/2011
2	Aftercare (After-Treatment) 09/2020 - 03/2014
2	Hematopoietic Stem Cell Transplantation 01/2016 - 08/2014
1	Stem Cell Transplantation 01/2015
1	Injections 06/2011
1	Intravenous Administration 05/2011